Synthesis and Evaluating of Nanoporous Molecularly Imprinted Polymers for Extraction of Quercetin as a Bioactive Component of Medicinal Plants

Authors

  • Ali Akbar Moghadamnia Department of Pharmacology, Babol University of Medical Sciences, Babol, Mazandaran, I.R. IRAN
  • Ali Ramazani Department of Chemistry, University of Zanjan, P. O. Box 45195-313 Zanjan, I.R. IRAN
  • Alireza Amiri Department of Chemistry, University of Zanjan, P. O. Box 45195-313 Zanjan, I.R. IRAN
  • Mohsen Jahanshahi Nanotechnology Research Institute, Babol Noshirvani University of Technology, Mazandaran, I.R. IRAN
Abstract:

In this work, the template, monomer, and cross-linker with the ratio of 1:8:40 were used to synthesize Molecularly Imprinted Polymers (MIPs) for extraction of the bioactive chemical compounds from some traditional herbs as a sorbent material. Quercetin, Methacrylic Acid (MAA), Trimethylolpropanetrimethacrylate (TRIM) and Tetrahydrofuran (THF) were used as a template, functional monomer, cross-linker, and porogen, respectively. Polymer particles have been evaluated by Atomic Force Microscopy (AFM), Field Emission Scan Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM) and Brunauer–Emmett–Teller (BET). The produced nanoporous MIPs, with a good specific surface area 167.899 m2/g comparatively to Non-Imprinted Polymers (NIPs), exhibited a good affinity to quercetin with the binding capacity of 392.08 mg/g in acetonitrile-water (1:1v/v). The results showed that the MIPs can be used as a sorbent. Thus, direct extraction of certain pharmacophoric components from herbal plants is considerable by MIPs technology. 

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Journal title

volume 35  issue 4

pages  11- 19

publication date 2016-12-01

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